Patients with serious cancers, such as advanced lung cancer, often experience physical and psychological symptoms that interfere with their ability to enjoy life. These patients must also engage in difficult conversations with clinicians about their wishes for care toward the end of life, such as whether to receive life-prolonging measures and when to stop cancer treatment and enroll in hospice. Involving palliative care clinicians in the care of patients with advanced cancer, beginning at the time of diagnosis and continuing throughout cancer treatment, can help improve patients’ symptoms, quality of life, and the care they receive at the end of life.